Role of Vitamins and minerals in the body

Thursday Sep 29, 2011 | Dr. Said | Comments Off on Role of Vitamins and minerals in the body

Vitamins control the chemical reactions within the body that convert food into energy and living tissue. Regulating the metabolism and assisting the biochemical process that releases energy from digested food. Vitamins help the body use the energy in nutrients, maintain normal body tissue, and act as a regulator.

Minerals are chemical elements needed for several body functions including building strong bones, transmitting nerve signals, maintaining a normal heart beat, and are used by the body to produce necessary hormones.

There are 13 vitamins and 22 minerals we have to get from our food supply. While only needed in small amounts, vitamins and minerals are nonetheless important because you cannot function biologically without them. According to a recent study, North Americans are lacking 72% of the nutrients they need daily. This is one of the reasons we need supplementation.

Do we need supplements?

A multiple vitamin-mineral supplement should not replace good eating habits, like the name suggests it is a supplement to the foods we eat. They  might not be for everyone, depending on your lifestyle factors and biochemical individuality, but most can benefit from taking a good quality and balanced supplement at the right dosage.

Many people take supplements that are not appropriate for  their needs because they randomly choose a product they heard about in the news or through a friend, or just picked something from their supermarket shelf. Remember, just as your diet is best customized to your unique needs, so should your supplements be tailored to your body type and blood work. Consult with your doctor, after blood work has been done.

Note: One basic problem with the health system in the U.S. is our doctors’ lack of knowledge about supplements and other nutrients. It is understandable why patients rely on other sources, so that much of what they believe is shaped by what they see, read, and hear, often from unreliable sources.

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7- Keto and Weight Loss?

Thursday Aug 18, 2011 | Jeff Sherman | Comments Off on 7- Keto and Weight Loss?

7-Keto is a weight loss supplement that is a metabolite of Dihydroepiandrosterone (DHEA).

DHEA (noun): 1. DiHydroEpinAndrosterone; 2. an endogenous steroid that has been implicated in a broad range of biological effects in humans and other mammals. DHEA is produced by the adrenal glands, gonads and the brain. (Wikipedia)

DHEA is naturally occurring in the human body and has been associated with treatment of:

  • Depression – DHEA antagonizes the production of cortisol
  • Memory – effective in treatment of short-term memory in healthy young males
  • Fertility – has been used in conjunction with fertility medications to increase the chromosomal integrity of eggs
  • Cardiovascular Disease – some studies have reported a lower risk of cardiovascular disease with increased levels
  • Diabetes – restores the oxidative balance in diabetic patients, which reduces tissue levels of pentosidine
  • Weight Loss – used as a weight loss supplement
7-Keto and Weight Loss

As DHEA breaks down (metabolizes) in the body, one of the products is 3-acety.-7-oxo-dehydroepiandrosterone (7-Keto-DHEA). For healthy adults with decreased DHEA serum levels, generally have low 7-Keto levels as well. Because the metabolite (7-Keto) does not convert into either testosterone or estrogen, the supplements are much safer than DHEA. The primary benefits of 7-Keto-DHEA are as follows:

  • Thermogenesis – 7-Keto is a fat burning compound. The heat supplied by your body during metabolism: as thermogenesis increases, so does fat burning and ultimately metabolism. This effective increase in metabolism will burn calories more quickly. A double-blind study published in “Current Therapeutic Research” revealed that overweight adults, consuming 1,800 calories/day, exercising 45 minutes three times a week,  and taking 7-Keto supplements lost an average of 4.24 pounds more than the control group (not taking 7-Keto). Body fat loss in the 7-Keto group averaged 1.8% as opposed to 0.57% in the control group. There was an increase in T3 levels in the 7-Keto patients, although the rates remained within normal limits.
  • Immune System Modulation – in addition to a Czech study that indicated 7-Keto’s reduction of cortisol in the system, the Minnesota Applied Research Center and Geriatric Research Education and Clinical Center in Minneapolis (2004) report that the immune system in men and women over 65 are improved with 7-Keto. The four-week study included 22 women and 20 men; each taking either 7-Keto or a placebo twice daily. The 7-Keto group showed significant increases in immune helper cells and significant decrease in immune suppressor cells. An increase in neutrophils (white blood cells) was also indicated.
Side Effects

With virtually no side effects, 7-Keto is a safe weight loss supplement. No increase in testosterone or estrogen levels is indicated when taking as much as 200 mg/day for eight weeks. Be advised that there are no long term studies to demonstrate the effects of 7-Keto on humans.

Because of the increased levels of T3, both the heart and bone mass could, theoretically be adversely affected. It is strongly recommended that you seek permission from your physician before taking 7-Keto (or any dietary supplement). This is especially important in patients with thyroid disorders or who are taking any thyroid hormones.

The only side effect reported is feeling jittery. This could be an indication of an underlying thyroid disorder. If you do experience a jittery feeling when taking 7-Keto, seek the advice of a physician immediately. To date, there have been no reports of drug interactions with 7-Keto, however, it is strongly advised that you seek permission from your physician before taking.

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The History of Fish Oil as a Beneficial Health Supplement

Sunday Jul 31, 2011 | Jeff Sherman | Comments Off on The History of Fish Oil as a Beneficial Health Supplement

Fish oil has been used throughout history within fishing communities. Specifically, 16th century English fishermen used fish oil to treat a variety of health issues:

  • Wounds
  • Colds
  • Skin Diseases
  • Body Aches
Today we understand that fish oil contains Omega-3 fatty acids that are beneficial in treatment and prevention of numerous diseases.

Research

Studies conducted on Greenland Eskimos by Dutch scientists in the 1970s revealed that a diet including high-fat fish is extremely beneficial. The study indicated an extremely low incidence of cardiovascular disease, including heart attacks, was due to the Greenland Eskimo’s daily consumption of fish. Fish skin, which provides the Omega-3 fatty acids, is also high in the anti-inflammatories Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA).

Benefits of Fish Oil

In addition to the initial observance that fish oil is effective for treating cardiovascular disease, it has proven an effective for:

  1. Treating Depression/Bi-Polar Disorder, including Post-Partum Depression
  2. Reducing Cholesterol Levels
  3. Reducing Triglyceride Levels
  4. Reducing Inflammation
  5. Treatment of Skin Diseases
  6. Weight Loss
  7. Improving Brain Function
  8. Increasing Focus
  9. Improving Vision
  10. Treatment of Muscle Aches
  11. Relieving Symptoms of Chron’s Disease and Colitis
  12. Treatment of Ulcers
Fish oil is thought to be effective for:
  1. Slowing Breast Tumor Growth
  2. Easing Symptoms of Alzheimer’s Disease
If that isn’t enough, Iam’s Dog Food research states that fish oil, especially during the first month’s of a pup’s life provides many benefits to development and health including: brain development; improves vision; increases trainability.

Fish With Highest Levels of Omega-3s

The best fish to include in your regular diet that provide the highest levels of Omega-3 Fatty Acids are:

  • Wild Alaskan Salmon – farmed salmon negatively impacts natural sources
  • Arctic Char (Iwana) – wild or farmed
  • Atlantic Mackerel – not Spanish or King because mercury content is extremely high
  • Sardines – wild or canned (wild sardines do not contain high levels of mercury due to size)
  • Sablefish (Black Cod) – wild caught only off Alaska or British Columbia to prevent capture of other species
  • Anchovies – any species; small enough that contamination is not a concern
  • Oysters (Kaki) – wild or farmed
  • Rainbow Trout – only farmed, as wild sources (Great Lakes) have been overfished; children should limit to 2-3 servings per month because of high levels of PCB’s 
  • Albacore Tuna – only from U.S. or Canada that practice safe methods to avoid catching other species; moderate mercury contamination should limit children to 3-meals/month.
  • Mussels (Murugai) – since farmed mussels are raised with no impact on environment, this is the best choice
  • Pacific Halibut
Unless you are prepared to eat a minimum of 3-4 ounces of fish (as listed) every day, you will likely not maintain therapeutic levels of fish oil in your system. To sustain optimum level of Omega-3s in your body, fish oil supplements are a great source. Be certain that the supplements you choose are pharmaceutical grade, like Dr. S’s EPA/DHA FISH OIL supplements, to assure reaping the full benefits of the Omega-3s.

 

 

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What is a Limey? The History of Vitamin-C

Wednesday Jul 27, 2011 | Jeff Sherman | Comments Off on What is a Limey? The History of Vitamin-C

As early as 1512, Spanish explorer, Ponce de Leon was introduced to the healing qualities of ascorbic acid. When Native Americans shared sassafras tea with scurvy-ridden sailors, within 6-days, all symptoms had cleared. It was not until the 17th century that British Naval Surgeon, tested the effects of citrus on scurvy. He found that sailors given 1 lemon or orange per day resisted the disease, while those not receiving citrus fell victim to scurvy. As a result, concentrated lemon syrup became a staple in every Naval Surgeon’s medical kit. The Brits called the concoction ‘lime’, and British sailors were coined as ‘Limeys’.

It was not until 1928 that Vitamin-C was isolated and named by biochemist, Albert Szent-Gyorgyi. Gyorgyi isolated Vitamin-C in Hungarian paprika. Even then, it was not until the 1940s-1950s that Vitamin-C was manufactured in large doses; used to treat polio and other viral diseases.

Emergence of Vitamin-C in the Health Industry

The controversial  publication “Vitamin C, the Common Cold & the Flu”, written in 1970 by Linus Pauling, was the first to indicate that Vitamin-C is beneficial in larger quantities than current medical practitioners believed. Prior to Pauling’s publication, it was believed that only small quantities were needed. Pauling co-wrote a paper with Ewan Cameron (a Scottish surgeon) about Vitamin-C with regards to cancer. Cameron had anecdotal evidence that large quantities (up to 10 g) of the vitamin shrank some tumors. The paper was published by Oncology magazine after being rejected by the Proceedings of National Academy of Sciences.

Through the 1980s, Robert F. Cathcart III, M.D. studied the effects of Vitamin-C on treatment of infections, immune disorders, arthritis and even AIDS. He developed the method to determine the correct amount of Vitamin-C required for treatment of any illness or disease. After numerous studies regarding Vitamin-C, the Recommended Daily Allowance was established as 60 mg/day in 1989. Studies through the late-1980s included areas including (but not limited to):

  • Neurochemistry
  • Epidemiology
  • Biochemistry
  • Immunology
All of these studies were released through the New York Academy of Sciences Third Conference. Released at the same time were studies conducted with safety issues concerning Vitamin-C and on the following diseases:
  • Diabetes
  • Cataracts (other eye diseases as well)
  • Free Radicals
  • Metabolic Requirements

Natural Sources of Vitamin-C

Vitamin-C can be found in many fruits and vegetables:

> Citrus Fruits (lemons, limes, oranges, etc.)

> Melons (watermelon, cantaloupe, casaba, etc.)

> Berries (strawberries, blueberries, blackberries, rasberries, etc.)

> Other Fruits (kiwi, papaya, black currants, etc.)

> Leafy Green Vegetables (spinach, collard greens, etc.)

> Raw Vegetables (broccoli, cauliflower, brussel sprouts, etc.)

Although it is not difficult to sustain the RDA of 60 mg/day through your diet, to maintain the optimum suggested level of 500 mg/day could be difficult. As such, premium Vitamin-C supplements are strongly recommended by physicians to maintain levels.

A better way to take vitamin C:

Ascorbyl Palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitaminC. Unlike ascorbic acid , which is water-soluble, ascorbyl Palmitate is not. Consequently ascorbyl Palmitate can be stored in cell membranes until it is required by the body. Many people think vitamin C (ascorbyl Palmitate) is only used for immune support, but it has many other important functions. A major role of vitamin C is in manufacturing collagen, a protein that forms the basis of connective tissue – the most abundant tisse in the body yes including (your face). Ascorbyl Palmitate is an effective free radical scavenging antioxidant which promotes skin health and vitality. Ascorbyl Palmitate, working at the cell membrane, has been shown to provide antioxidant action comparable or even greater than, that of vitamin E. It also acts synergistically with vitamin E, helping to regenerate the vitamin E radical on a constant basis.  My Book

 

 

 

 

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Why detoxification so critical to your health

Thursday Jun 2, 2011 | Dr. Said | Comments Off on Why detoxification so critical to your health

Everyday toxins invade our bodies from food we eat, the air we breathe, the water we drink and the cell-phone we use . With more than 80,000 chemicals used in the United States and 2,000 new compounds being introduced every year, the average American is exposed to a cocktail of chemicals. These toxins usually build up to unhealthy levels and weaken our immune system, causing us to be more susceptible to illness and disease.

If you regularly experience three or more of the symptoms on this list “It’s time to detox.”

Overweight
Tired or sluggish
Depression or mood swings
Gas,bloating,indigestion or constipation
Less than one bowel movement per day
Brittle or weak fingernails
Concentration difficulties
Sleeping disorders
Persistent colds and /or flu

IF you were perfectly healthy, your body would detox itself every day. If the body becomes overwhelmed and cannot detox itself naturally, then the process of cell reproduction is comprised and that spells big trouble. Over saturation means the body cannot detox fast enough, and it starts to make choices about what it needs to take care of first. Let’s say you are fighting a cold. Your body will fight the cold and leave toxins alone in other parts of the body. Let’s say you ate too much at a turkey dinner and you have too much to digest. Some of what you are will stay with you longer than it should. I tell my patients that they need to detox their bodies two times a year, much like see their dentist for a cleaning. Even though you brush and floss every day, you still make that extra effort. Your body needs the same type of maintenance.

Why detox?

  • More than one-third of individuals born in the U.S. in the year 2000 are expected to develop diabetes.
  • In 2008, 64.5% of Americans were overweight and 30.5% were obese.
  • Prevalence of depression and age-adjusted prevalence of osteoporosis are increasing.
  • Congestive heart failure increased by 118% from 1979 to 1992.
  • Migraine prevalence increased from 1980 to 1989.
  • Asthma increased 75% from 1980 to 1999.

And if you don’t think these statistics are affecting you personally, think again

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Toxic effects of Tyramine

Tuesday May 3, 2011 | Dr. Said | Comments Off on Toxic effects of Tyramine

Tyramine is a natural substance formed from the breakdown of protein as food are ageds, fermented, salted, smoked, Aged cheese, pickled or spoiled foods for vegetable (fava or broad beans, sauerkraut, olives any fermented soy products(ie miso,soy sauce, teriyaki sauce). Watch out especially for pepperoni, salami and liverwurst. The longer a high-protein food ages, the greater the tyramine content. tyramine-free diet is prescribed  for people who are sensitive to tyramine, such as migraine sufferers, or those taking prescription antidepressants MAOI (monoamine oxidase inhibitor) such as phenelzine. Food high in tyramine include aged cheeses: blue, boursault, boursin, brick (natural), brie, Camembert, cheddar, Colby, Emmenthaler, Gruyere, mozzarella, Parmesan, Provolone, Romano, Requefort, and swiss.It can also be found in american cheese, gouda, processed cheese, sour cream, and yogurt. Alcoholic beverages should be avoided during a tyramine cleanse.

Toxic effect of tyramine

The toxic effects of tyramine are often described as “cheese effect,” especially when tyramine-induced damage occurs as result of use of MAO inhibitors. Tyramine can increase blood pressure (increasing the risk of hypertension) by causing the release of catecholamines, especially in the presence of MAO inhibitor drugs. People with high levels of Candida albicans (yeast) should avoid tyramine-containing foods. Some people suffer from food allergies due to tyramine, causing the release of histamine from mast cell leading to the allergic reaction. Tyramine can cause anxiety, mood swing, depression, migraines or headaches by overstimulating the adrenal gland, resulting in the depleting of the body”s norepinephrine reserves. Tyramine can cause over stimulating of autonomic nervous system as well.

You can read more in my Book


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Role of Vitamin A

Monday Apr 25, 2011 | Dr. Said | Comments Off on Role of Vitamin A

Vitamin A is a generic term for a large number of related compounds. Vitamin A, a fat-soluble vitamin, plays essential roles in vision, growth, and development. The development and  maintenance  of health skin, hair, and mucous membranes:immune functions: and reproduction can be attributed to vitamin A. It also serves as a great antioxidants. Retinol (an alcohol) and retinal (an aldehyde) are often referred to as preformed vitamin A. Retinol is pure and an active vitamin A. Another well known, synthetic form of vitamin A is tretinoin, better known as Retin-A®. vitamin A is one of the few substances with small enough molecular structure to penetrate  the outer layers of the skin. This allow vitamin A to work at repairing the lower layers of the skin where collagen and elastin reside. It stimulates collagen and elastin, creating firmer, smoother skin. This is a good alternative for those with sensitive skin who cannot tolerate tretinoin. Beta-carotene and other carotenoids that can be converted by the body into retinol are referred to as pro vitamin A carotenoids. Hundred of different carotenoids are synthesized by plants, but only 10%of them are pro vitamin A carotenoids. The site of absorption of vitamin A is the small intestine. Good source of vitamin A are in yellow and dark green leafy vegetables, oranges, milk fat, and organ foods such as liver and kidneys.

A survey of over 15,000 adults showed that people with the highest levels of carotenes had about 60% less risk of death from any cause than those with lower levels of vitamin A. When vitamin A status was categorized into four groups from highest to lowest, the risk of death from any cause got progressively lower, even after lifestyle and demographics were taken into account. (Archives of Internal Medicine, March 2011)

Health benefits of Vitamin A:

Vitamin A improves the stability of cell membranes by protecting the fatty acids contained in cell membranes.Vitamin A maintains and tones the epithelial cell (Epithelium cell is one of the four basic types of  animal tissue, along with connective tissue, muscle tissue and nervous tissue) that form the outer protective layer of skin, as well as mucous membranes.

Vitamin A deficiency may exacerbate iron deficiency anemia. Not having enough Vitamin A in your system increase susceptibility to bacteria and viral diseases.

Vitamin A deficiency can also cause the degeneration and atrophy of the spleen.

Vitamin A used in conjunction with vitamin C, can alleviate halitosis and heartburn.

Vitamin A can assist in the prevention of basal cell carcinoma, breast cancer, cervical cancer, colon cancer, and liver cancer.

You can read more from my book

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Food that should be eaten organically

Wednesday Apr 20, 2011 | Dr. Said | Comments Off on Food that should be eaten organically

Baby food : According to the National Academy of sciences federal pesticide standards too little health protection.

 

 

 

 

 

 

Strawberries: A 1993 study by the environmental Working Group found that supermarket strawberries were the most heavily contaminated fruit or vegetable in the U.S.

 

 

 

 

 

Rice : Water-soluble herbicides and insecticides have contaminated the groundwater near Rice fields. buy organic wild rice and brown rice.

 

 

 

 

 

Oats: In 1994, FDA found illegal residues in a year’s worth of Cheerios manufactured by General Mills. Organic growers provide Oats, Millet, Quinoa, Barley, couscous, Amaranth and Spelt as healthy options. Use organic steel cut Oats.

 

 

 

 

Milk: dairy companies inject cows with recombinant bovine growth hormone. seventy-nine percent of treated cows get clinical mastitis, a common udder infection treating with antibiotics increases the chance of antibiotic residue in milk. Another toxic aspect of milk is Xanthin Oxidase, which would normally be rejected by your body, but homogenization causes the human digestive system to absorb it, an enzyme of bovine milk. This enzyme will clog the arteries, cause premature aging, cause free radicals, and increase your chance for Gout by increasing Uric acid. Do not consume milk; if you do, choose organic milk (goat), which is widely available.

 

 

 

 

 

Bell peppers: The FDA found that in 1993, 38% of the peppers from Mexico, which provides 98% of the U.S. supply, had two or more toxic pesticides within the pepper.

 

 

 

 

Bananas: Costa Rica uses 35% of the country’s pesticide on Banana crops. This pesticide is not sprayed, but rather is absorbed.

Oxford JournalsMedicineInternational Journal of Epidemiology >Volume25, Issue6 > Pp. 1125-1131 ( Costa Rica has population and disease registries with potential value for epidemiological research. Pesticides have been intensively used on banana plantations, for example dibromochloropropane (DBCP). This study was planned to examine the quality of the cancer and civil registries and the feasibility of record linkages, and to explore cancer pattems among a highly exposed group.

 

 

 

 

Green beans: Sixty pesticides are used on green beans. Ten percents of Mexico green beans are contaminated with pesticides that are illegal in the U.S.

 

 

 

 

 

Peaches: The FDA cited peaches for above-averge rate of illegal pesticide violation; 5% of the crop was contaminated.

Anything your kids eat more than three times a week. Using organic food will lessen the accumulation of pesticides in their bodies.

you can read more in my Book.

 

 

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What you need to know about ascorbic acid (Vitamin C)

Wednesday Apr 6, 2011 | Dr. Said | Comments Off on What you need to know about ascorbic acid (Vitamin C)

Ascorbic acid is the simplest most readily available form of vitamin C. However, since ascorbic acid is water soluble,the body will always have problems storing it. While the absorption of water soluble vitamin C is quite quick, itspenetration into cell is limited. Unlike vitamin E, a fat soluble vitamin, vitamin cis not stored in the body.This makes ascorbyl Palmitate, a fat soluble form of vitamin C supplementation very attractive.  There is a chemical process in which vitamin C can be made in a lab and

it can even legally be labeled as vitamin C, which is very misleading to consumers. This processed type of C is missing 80% of what constitutes food grade vitamin C. Even worse, researchers from the University of California reported in 2000 that people who took 500mg of ascorbic acid had 2.5 times faster progression of hardening of the arteries than people who took no supplements at all.

A better way to take vitamin C:

Ascorbyl Palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitaminC. Unlike ascorbic acid , which is water-soluble, ascorbyl Palmitate is not. Consequently ascorbyl Palmitate can be stored in cell membranes until it is required by the body. Many people think vitamin C (ascorbyl Palmitate) is only used for immune support, but it has many other important functions. A major role of vitamin C is in manufacturing collagen, a protein that forms the basis of connective tissue – the most abundant tisse in the body yes including (your face). Ascorbyl Palmitate is an effective free radical scavenging antioxidant which promotes skin health and vitality. Ascorbyl Palmitate, working at the cell membrane, has been shown to provide antioxidant action comparable or even greater than, that of vitamin E. It also acts synergistically with vitamin E, helping to regenerate the vitamin E radical on a constant basis.  My Book



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Protecting Yourself from Radiation

Tuesday Mar 22, 2011 | Dr. Said | Comments Off on Protecting Yourself from Radiation
 

How protecting yourselves against any radiation which might be coming your way. To put things into perspective, anything over a radioactive level of 46 is dangerous.  After the Chernobyl disaster the infant mortality rate went up 900% in the Boston area. We must protect our children as high levels of radiation can prevent them in the future from reproduction disorders.

This is a time of shift to awaken everyone to what is real, what is important… Please read the protocol, tune in and do what’s right for you. And I ask that you send this out to everyone you know to give them a chance to do the same. Knowledge is power.

How Protecting Yourself from Radiation

• 5 kelp tablets daily  (the body will absorb the kelp instead of radiation)
• Ioderol – 100 mc (micrograms) daily – more effective than the kelp tabs
• Natural Cellular Defense– a cocktail of antioxidants (selenium, vitamin C as Ascorbyl palmitate exhibits powerful antioxidant properties to help protect cells from free radical damage and maintain normal connective tissue, N-acetyl Cysteine, alpha-lipoic acid, and co-enzyme Q10) started 24 hours after a lethal level of radiation exposure has been shown to be highly protective.  Oral chelation of the body’s tissues from such things as Heavy Metal Toxicity not only should be considered, but, during these ominous times these recommended products are meant to assist the neuro-transmitters of the brain such as our propriety formula Detox.
• Foods and supplements high in antioxidants
• Potassium rich foods (avocados, deep leafy greens, sea veges) – these protect against cesium poisoning
• Soy-based organic and non-gmo (miso soup)
•  iron (plant based only) if you are Iron deficient, spirulina, chlorella – to protect yourself from plutonium poisoning.

  • Whole grains provide vitamin B6, which is indispensable for the thymus. In addition, their calcium content guards against uptake of radioactive strontium, and their vitamin E and selenium prevent cellular damage caused by free radicals.

DO NOT CONSUME:

• Any forms of dairy (milk, yogurt, ice cream, cheese).and meat as concentrated levels of radioactivity are stored in the cows after they feed from the grass and drink the water.

  • Refined, genetic modified and processed foods
  • Simple sugars (white sugar), soft drinks
Radiat Res. 2010 Apr;173(4):462-8.

Antioxidant diet supplementation starting 24 hours after exposure reduces radiation lethality.

Source

Henry Ford Hospital, Department of Radiation Oncology, Detroit, Michigan 48202, USA. sbrown1@hfhs.org

Abstract

Antioxidants mitigate radiation-induced lethality when started soon after radiation exposure, a delivery time that may not be practical due to difficulties in distribution and because the oral administration of such agents may require a delay beyond the prodromal stage of the radiation syndrome. We report the unexpected finding that antioxidant supplementation starting 24 h after total-body irradiation resulted in better survival than antioxidant supplementation started soon after the irradiation. The antioxidant dietary supplement was l-selenomethionine, sodium ascorbate, N-acetyl cysteine, alpha-lipoic acid, alpha-tocopherol succinate, and co-enzyme Q10. Total-body irradiation with 8 Gy in the absence of antioxidant supplementation was lethal by day 16. When antioxidant supplementation was started soon after irradiation, four of 14 mice survived. In contrast, 14 of 18 mice receiving antioxidant supplementation starting 24 h after irradiation were alive and well 30 days later. The numbers of spleen colonies and blood cells were higher in mice receiving antioxidant supplementation starting 24 h after irradiation than in mice receiving radiation alone. A diet supplemented with antioxidants administered starting 24 h after total-body irradiation improved bone marrow cell survival and mitigated lethality, with a radiation protection factor of approximately 1.18.

PMID:
20334518
[PubMed – indexed for MEDLINE]
PMCID: PMC2874934


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